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KMID : 0828520150190010034
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Journal of the Korean Geriatrics Society
2015 Volume.19 No. 1 p.34 ~ p.39
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Hyperinsulinemic Hypoglycemia Caused by Acute Reduction of Renal Function on an Eldery Patient Without Diabetes
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Yeo Ji-Hyun
Kim Jeong-Eun
Park Eun-Sik
Park Jung-Hwan
Kim Dong-Sun
Choi Woong-Hwan
Ahn You-Hern
Kim Ho-Jung
Hong Sang-Mo
Lee Chang-Beom
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Abstract
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In patient with renal failure, hypoglycemia may develop because of decreased caloric intake, diminished renal insulin degradation and clearance, reduced renal gluconeogenesis and hepatic glucose production, impaired release of counterregulatory hormone such as glucagon and epinephrine. We report here on a 80-year-old female patient with hypoglycemia due to endogenous hyperinsulinemia with acute kidney injury. She had chronic kidney disease and had no history of diabetes mellitus or insulin use. She had experienced recurrent hypoglycemia despite of intravenous dextrose injection and eventually generalized tonic clonic seizure occurred as a result of hypoglycemia. As serum creatinine level decreases, serum insulin and C-peptide level decreased and hypoglycemia was not occurred. We present this case along with a review of the literature.
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KEYWORD
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Acute renal injury, Hypoglycemia, Hyperinsulinemia
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